4-hydroxyphenylacetate decarboxylase explained

4-hydroxyphenylacetate decarboxylase
Ec Number:	4.1.1.83
Go Code:	0043722

The enzyme 4-hydroxyphenylacetate decarboxylase catalyzes the chemical reaction

(4-hydroxyphenyl)acetate + H⁺

\rightleftharpoons 4-methylphenol + CO₂

This enzyme belongs to the family of lyases, specifically the carboxy-lyases, which cleave carbon-carbon bonds. The systematic name of this enzyme class is 4-(hydroxyphenyl)acetate carboxy-lyase (4-methylphenol-forming). Other names in common use include p-hydroxyphenylacetate decarboxylase, p-Hpd, 4-Hpd, and 4-hydroxyphenylacetate carboxy-lyase.

References

• D'Ari L, Barker HA . 1985 . p-Cresol formation by cell-free extracts of Clostridium difficile . Arch. Microbiol. . 143 . 311–2 . 3938267 . 10.1007/BF00411256 . 3 .
• Selmer T, Andrei PI . 2001 . p-Hydroxyphenylacetate decarboxylase from Clostridium difficile. A novel glycyl radical enzyme catalysing the formation of p-cresol . Eur. J. Biochem. . 268 . 1363–72 . 11231288 . 10.1046/j.1432-1327.2001.02001.x . 5 . free .
• Andrei PI, Pierik AJ, Zauner S, Andrei-Selmer LC, Selmer T . 2004 . Subunit composition of the glycyl radical enzyme p-hydroxyphenylacetate decarboxylase. A small subunit, HpdC, is essential for catalytic activity . Eur. J. Biochem. . 271 . 2225–30 . 15153112 . 10.1111/j.1432-1033.2004.04152.x . 11 . free .