4-hydroxyphenylacetaldehyde dehydrogenase explained

4-hydroxyphenylacetaldehyde dehydrogenase
Ec Number:	1.2.1.53
Cas Number:	109456-56-6
Go Code:	0047106

In enzymology, a 4-hydroxyphenylacetaldehyde dehydrogenase is an enzyme that catalyzes the chemical reaction

4-hydroxyphenylacetaldehyde + NAD⁺ + H₂O

\rightleftharpoons 4-hydroxyphenylacetate + NADH + 2 H⁺

The 3 substrates of this enzyme are 4-hydroxyphenylacetaldehyde, NAD⁺, and H₂O, whereas its 3 products are 4-hydroxyphenylacetate, NADH, and H⁺.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the aldehyde or oxo group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is 4-hydroxyphenylacetaldehyde:NAD+ oxidoreductase. This enzyme is also called 4-HPAL dehydrogenase. This enzyme participates in tyrosine metabolism.

References

• Cuskey SM, Peccoraro V, Olsen RH . 1987 . Initial catabolism of aromatic biogenic amines by Pseudomonas aeruginosa PAO: pathway description, mapping of mutations, and cloning of essential genes . J. Bacteriol. . 169 . 2398–404 . 3034855 . 6 . 212074 .