4-Hydroxybutyrate dehydrogenase explained

4-hydroxybutyrate dehydrogenase
Ec Number:	1.1.1.61
Go Code:	0047577
Width:	270

In enzymology, a 4-hydroxybutyrate dehydrogenase is an enzyme that catalyzes the chemical reaction

4-hydroxybutanoate + NAD⁺

\rightleftharpoons succinate semialdehyde + NADH + H⁺

The two substrates of this enzyme are therefore 4-hydroxybutanoic acid, and NAD⁺, whereas its 3 products are succinate semialdehyde, NADH, and H⁺.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD⁺ or NADP⁺ as acceptor.^[1] The systematic name of this enzyme class is 4-hydroxybutanoate:NAD⁺ oxidoreductase. This enzyme is also called gamma-hydroxybutyrate dehydrogenase. This enzyme participates in butanoate metabolism and the degradation of the neurotransmitter 4-hydroxybutanoic acid.^[2]

Notes and References

1. Nirenberg MW, Jakoby WB. 1960 . Enzymatic utilization of gamma-hydroxybutyric acid . J. Biol. Chem. . 235 . 954 - 960 . 14427301.
2. Kaufman EE, Nelson T . An overview of gamma-hydroxybutyrate catabolism: the role of the cytosolic NADP⁺-dependent oxidoreductase EC 1.1.1.19 and of a mitochondrial hydroxyacid-oxoacid transhydrogenase in the initial, rate-limiting step in this pathway . Neurochem. Res. . 16 . 9 . 965–974 . 1991 . 1784339 . 10.1007/BF00965839.