4-hydroxybenzoyl-CoA reductase explained

In enzymology, a 4-hydroxybenzoyl-CoA reductase is an enzyme found in some bacteria and archaea that catalyzes the chemical reaction^{[1] [2]}

benzoyl-CoA + acceptor + H₂O

\rightleftharpoons 4-hydroxybenzoyl-CoA + reduced acceptor

The 3 substrates of this enzyme are benzoyl-CoA, acceptor, and H₂O, whereas its two products are 4-hydroxybenzoyl-CoA and reduced acceptor.

This enzyme participates in benzoate degradation via coa ligation.

Nomenclature

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-CH group of donor with other acceptors. The systematic name of this enzyme class is benzoyl-CoA:acceptor oxidoreductase. Other names in common use include:

• 4-hydroxybenzoyl-CoA reductase (dehydroxylating), and
• 4-hydroxybenzoyl-CoA:(acceptor) oxidoreductase.

Further reading

• Breese K, Fuchs G . 1998 . 4-Hydroxybenzoyl-CoA reductase (dehydroxylating) from the denitrifying bacterium Thauera aromatica--prosthetic groups, electron donor, and genes of a member of the molybdenum-flavin-iron-sulfur proteins . Eur. J. Biochem. . 251 . 916–23 . 9490068 . 10.1046/j.1432-1327.1998.2510916.x . 3 . free .
• Brackmann R, Fuchs G . 1993 . Enzymes of anaerobic metabolism of phenolic compounds 4-Hydroxybenzoyl-CoA reductase (dehydroxylating) from a denitrifying Pseudomonas species . Eur. J. Biochem. . 213 . 563–71 . 8477729 . 10.1111/j.1432-1033.1993.tb17795.x . 1 . free .
• Heider J, Fuchs G . 1997 . Anaerobic metabolism of aromatic compounds . Eur. J. Biochem. . 243 . 577–96 . 9057820 . 10.1111/j.1432-1033.1997.00577.x . 3 . free .

Notes and References

1. Glockler R, Tschech A, Fuchs G . 1989 . Reductive dehydroxylation of 4-hydroxybenzoyl-CoA to benzoyl-CoA in a denitrifying, phenol-degrading Pseudomonas species . FEBS Lett. . 251 . 237–40 . 2753161 . 10.1016/0014-5793(89)81461-9 . 1–2 . 34285295 . free .
2. Heider J, Boll M, Breese K, Breinig S, Ebenau-Jehle C, Feil U, Gad'on N, Laempe D, Leuthner B, Mohamed ME, Schneider S, Burchhardt G, Fuchs G . Differential induction of enzymes involved in anaerobic metabolism of aromatic compounds in the denitrifying bacterium Thauera aromatica . Arch. Microbiol. . 170 . 2 . 120–31 . August 1998 . 9683649 . 10.1007/s002030050623 . 34536644 .