4-hydroxybenzoate decarboxylase explained

4-hydroxybenzoate decarboxylase
Ec Number:	4.1.1.61
Cas Number:	37290-53-2
Go Code:	0018799

The enzyme 4-hydroxybenzoate decarboxylase catalyzes the chemical reaction

4-hydroxybenzoate

\rightleftharpoons phenol + CO₂

This enzyme belongs to the family of lyases, specifically the carboxy-lyases, which cleave carbon-carbon bonds. The systematic name of this enzyme class is 4-hydroxybenzoate carboxy-lyase (phenol-forming). Other names in common use include p-hydroxybenzoate decarboxylase, and 4-hydroxybenzoate carboxy-lyase. This enzyme participates in benzoate degradation via CoA ligation.

References

• Grant DJ, Patel JC . The non-oxidative decarboxylation of p-hydroxybenzoic acid, gentisic acid, protocatechuic acid and gallic acid by Klebsiella aerogenes (Aerobacter aerogenes) . Antonie van Leeuwenhoek . 35 . 3 . 325–43 . 1969 . 5309907 . 10.1007/BF02219153 .
• Tschech A, Fuchs G . 1989 . Anaerobic degradation of phenol via carboxylation to 4-hydroxybenzoate - in vitro study of isotope exchange between (CO2)-C-14 and 4-hydroxybenzoate . Arch. Microbiol. . 152 . 594 - 599 . 10.1007/BF00425493 . 6 .