| 4-Hydroxybenzoate—CoA ligase | |
| Ec Number: | 6.2.1.27 |
| Cas Number: | 119699-80-8 |
| Go Code: | 0018859 |
In enzymology, a 4-hydroxybenzoate—CoA ligase is an enzyme that catalyzes the chemical reaction
ATP + 4-hydroxybenzoate + CoA
\rightleftharpoons
The 3 substrates of this enzyme are ATP, 4-hydroxybenzoate, and CoA, whereas its 3 products are AMP, diphosphate, and 4-hydroxybenzoyl-CoA.
This enzyme belongs to the family of ligases, specifically those forming carbon-sulfur bonds as acid-thiol ligases. The systematic name of this enzyme class is 4-hydroxybenzoate:CoA ligase (AMP-forming). Other names in common use include 4-hydroxybenzoate-CoA synthetase, 4-hydroxybenzoate-coenzyme A ligase (AMP-forming), 4-hydroxybenzoyl coenzyme A synthetase, and 4-hydroxybenzoyl-CoA ligase. This enzyme participates in benzoate degradation via coa ligation.