4-hydroxy-tetrahydrodipicolinate reductase explained

4-hydroxy-tetrahydrodipicolinate reductase
Ec Number:	1.17.1.8
Cas Number:	9055-46-3
Go Code:	0008839
Width:	270

In enzymology, a 4-hydroxy-tetrahydrodipicolinate reductase is an enzyme that catalyzes the chemical reaction

(S)-2,3,4,5-tetrahydropyridine-2,6-dicarboxylate + NAD(P)⁺ + H₂O

\rightleftharpoons (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate + NAD(P)H + H⁺

The 3 substrates of this enzyme are (S)-2,3,4,5-tetrahydropyridine-2,6-dicarboxylate, NAD⁺ or NADP⁺, and H₂O, whereas its 3 products are (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate, NADH or NADPH, and H⁺.

This enzyme participates in lysine biosynthesis.

Nomenclature

This enzyme belongs to the family of oxidoreductases, specifically those acting on CH or CH₂ groups with NAD⁺ or NADP⁺ as acceptor. The systematic name of this enzyme class is (S)-2,3,4,5-tetrahydropyridine-2,6-dicarboxylate:NAD(P)+ 4-oxidoreductase. Other names in common use include:

• dihydrodipicolinate reductase,
• dihydrodipicolinic acid reductase, and
• 2,3,4,5-tetrahydrodipicolinate:NAD(P)+ oxidoreductase.

Further reading

• Farkas W, Gilvarg C . The reduction step in diaminopimelic acid biosynthesis . The Journal of Biological Chemistry . 240 . 12 . 4717–22 . Dec 1965 . 10.1016/S0021-9258(18)97014-6 . 4378965 . free .
• Book: Tamir H . 1971 . Dihydrodipicolinic acid reductase (Escherichia coli) . Methods Enzymol. . 17B . 134 - 139 . 10.1016/0076-6879(71)17030-9. 978-0-12-181877-7 .
• Devenish SR, Blunt JW, Gerrard JA . NMR studies uncover alternate substrates for dihydrodipicolinate synthase and suggest that dihydrodipicolinate reductase is also a dehydratase . Journal of Medicinal Chemistry . 53 . 12 . 4808–12 . Jun 2010 . 20503968 . 10.1021/jm100349s .