4-chlorobenzoyl-CoA dehalogenase explained

4-chlorobenzoyl-CoA dehalogenase
Ec Number:	3.8.1.7
Cas Number:	141583-18-8
Go Code:	0018787

In enzymology, a 4-chlorobenzoyl-CoA dehalogenase is an enzyme that catalyzes the chemical reaction

4-chlorobenzoyl-CoA + H₂O

\rightleftharpoons 4-hydroxybenzoyl CoA + chloride

Thus, the two substrates of this enzyme are 4-chlorobenzoyl-CoA and H₂O, whereas its two products are 4-hydroxybenzoyl CoA and chloride.

This enzyme belongs to the family of hydrolases, specifically those acting on halide bonds in carbon-halide compounds. The systematic name of this enzyme class is 4-chlorobenzoyl CoA chlorohydrolase. This enzyme participates in 2,4-dichlorobenzoate degradation.

References

• Chang KH, Liang PH, Beck W, Scholten JD, Dunaway-Mariano D . 1992 . Isolation and characterization of the three polypeptide components of 4-chlorobenzoate dehalogenase from Pseudomonas sp. strain CBS-3 . Biochemistry . 31 . 5605–10 . 1610806 . 10.1021/bi00139a025 . 24 .
• Crooks GP, Copley SD . 1994 . Purification and characterization of 4-chlorobenzoyl CoA dehalogenase from Arthrobacter sp. strain 4-CB1 . Biochemistry . 33 . 11645–9 . 7918379 . 10.1021/bi00204a028 . 38 .