4-chlorobenzoate—CoA ligase explained
| 4-Chlorobenzoate—CoA ligase |
| Ec Number: | 6.2.1.33 |
| Cas Number: | 141583-20-2 |
| Go Code: | 0018861 |
In enzymology, a 4-chlorobenzoate—CoA ligase is an enzyme that catalyzes the chemical reaction
4-chlorobenzoate + CoA + ATP
4-chlorobenzoyl-CoA + AMP + diphosphate
The 3 substrates of this enzyme are 4-chlorobenzoate, CoA, and ATP, whereas its 3 products are 4-chlorobenzoyl-CoA, AMP, and diphosphate.
This enzyme belongs to the family of ligases, specifically those forming carbon-sulfur bonds as acid-thiol ligases. The systematic name of this enzyme class is 4-chlorobenzoate:CoA ligase. This enzyme participates in 2,4-dichlorobenzoate degradation. It employs one cofactor, magnesium.
Structural studies
As of late 2007, two structures have been solved for this class of enzymes, with PDB accession codes and .
References
- Dunaway-Mariano D, Babbitt PC . 1994 . On the origins and functions of the enzymes of the 4-chlorobenzoate to 4-hydroxybenzoate converting pathway . Biodegradation . 5 . 259–76 . 7765837 . 10.1007/BF00696464 . 3–4 . 13250105 .
- Loffler F, Muller R, Lingens F . 1992 . Purification and properties of 4-halobenzoate-coenzyme A ligase from Pseudomonas sp. CBS3 . Biol. Chem. Hoppe-Seyler . 373 . 1001–7 . 1418673 . 10 . 10.1515/bchm3.1992.373.2.1001.
- Chang KH, Liang PH, Beck W, Scholten JD, Dunaway-Mariano D . 1992 . Isolation and characterization of the three polypeptide components of 4-chlorobenzoate dehalogenase from Pseudomonas sp. strain CBS-3 . Biochemistry . 31 . 5605–10 . 1610806 . 10.1021/bi00139a025 . 24 .
