4-carboxymuconolactone decarboxylase explained

4-carboxymuconolactone decarboxylase
Ec Number:4.1.1.44
Cas Number:37289-46-6
Go Code:0047575

The enzyme 4-carboxymuconolactone decarboxylase catalyzes the chemical reaction

2-carboxy-2,5-dihydro-5-oxofuran-2-acetate

\rightleftharpoons

4,5-dihydro-5-oxofuran-2-acetate + CO2

This enzyme belongs to the family of lyases, specifically the carboxy-lyases, which cleave carbon-carbon bonds. The systematic name of this enzyme class is 2-carboxy-2,5-dihydro-5-oxofuran-2-acetate carboxy-lyase (4,5-dihydro-5-oxofuran-2-acetate-forming). Other names in common use include gamma-4-carboxymuconolactone decarboxylase, and 4-carboxymuconolactone carboxy-lyase. This enzyme participates in benzoate degradation via hydroxylation.

Structural studies

As of late 2007, only one structure has been solved for this class of enzymes, with the PDB accession code .

References