4-Aminoquinoline Explained

See also: 8-Aminoquinoline. 4-Aminoquinoline is a form of aminoquinoline with the amino group at the 4-position of the quinoline. The compound has been used as a precursor for the synthesis of its derivatives.^[1]

A variety of derivatives of 4-aminoquinoline are antimalarial agents useful in treating erythrocytic plasmodial infections.^[2] Examples include amodiaquine, chloroquine, and hydroxychloroquine.^[3] Other uses for the derivatives are: anti-asthmatic, antibacterial, anti-fungal, anti-malarial, antiviral and anti-inflammatory agents.

A patent application for 4-aminoquinoline compounds was filed in 2002 and published in 2005.^[4]

See also

• Quinoline
• 8-Hydroxyquinoline
• Ionophore

External links

• Bourne SA, De Villiers K, Egan TJ . Three 4-aminoquinolines of antimalarial interest . Acta Crystallogr C . 62 . Pt 2 . o53–7 . 2006 . 16456284 . 10.1107/S0108270105041235 . 2006AcCrC..62O..53B .
• "4-Aminoquinoline 578-68-7 | TCI America". www.tcichemicals.com. Retrieved 2020-03-06.

Notes and References

1. Al-Ahmary. Khairia M.. Alenezi. Maha S.. Habeeb. Moustafa M.. 2016-08-01. Synthesis, spectroscopic and DFT theoretical studies on the hydrogen bonded charge transfer complex of 4-aminoquinoline with chloranilic acid. Journal of Molecular Liquids. en. 220. 166–182. 10.1016/j.molliq.2016.04.074. 0167-7322.
2. Bosak. Anita. Opsenica. Dejan M.. Šinko. Goran. Zlatar. Matija. Kovarik. Zrinka. 2019-08-01. Structural aspects of 4-aminoquinolines as reversible inhibitors of human acetylcholinesterase and butyrylcholinesterase. Chemico-Biological Interactions. en. 308. 101–109. 10.1016/j.cbi.2019.05.024. 31100281. 2019CBI...308..101B . 157067252 . 0009-2797.
3. Bray PG, Hawley SR, Ward SA . 4-Aminoquinoline resistance of Plasmodium falciparum: insights from the study of amodiaquine uptake . Mol. Pharmacol. . 50 . 6 . 1551–8 . 1996 . 8967977 .
4. News: DeVita. Robert. 4-Aminoquinoline Compounds. United States Patent Application Publication. Chang. Lehua. 13 January 2005.