4-alpha-glucanotransferase explained
| 4-alpha-glucanotransferase |
| Ec Number: | 2.4.1.25 |
| Cas Number: | 9032-09-1 |
| Go Code: | 0004134 |
In enzymology, a 4-alpha-glucanotransferase is an enzyme that catalyzes a chemical reaction that transfers a segment of a 1,4-alpha-D-glucan to a new position in an acceptor carbohydrate, which may be glucose or a 1,4-alpha-D-glucan.
This enzyme belongs to the family of glycosyltransferases, specifically the hexosyltransferases. The systematic name of this enzyme class is 1,4-alpha-D-glucan:1,4-alpha-D-glucan 4-alpha-D-glycosyltransferase. Other names in common use include disproportionating enzyme, dextrin glycosyltransferase, D-enzyme, debranching enzyme maltodextrin glycosyltransferase, amylomaltase, and dextrin transglycosylase. This enzyme participates in starch and sucrose metabolism in plants.[1] [2] Studies of the enzyme from potato led to the discovery of cycloamylose.[3]
Structural studies
As of late 2007, 14 structures have been solved for this class of enzymes, with PDB accession codes,,,,,,,,,,,,, and .
References
- Hehre EJ . Enzymic synthesis of polysaccharides: a biological type of polymerization . 1951 . Advances in Enzymology and Related Areas of Molecular Biology . 11 . 297 - 337 . 10.1002/9780470122563.ch6 . Advances in Enzymology - and Related Areas of Molecular Biology . 24540594 . 978-0-470-12256-3 .
- Lukomskaya . I. S. . 1959 . Synthesis of oligosaccharides with alpha-1,6-bonds by enzyme preparations from liver and muscle . Russian . . 129 . 1172 - 1175 . Синтез oligosaccharides с alpha-1,6-bonds приготовлениями фермента от печени и мускула.
- Pazur JH, Okada S . 1968 . The isolation and mode of action of a bacterial glucanosyltransferase . J. Biol. Chem. . 243 . 4732 - 8 . 4972097 . 18 .
- Walker GJ, Whelan WJ. 1959 . Synthesis of amylose by potato D-enzyme . Nature . 183 . 46 . 10.1038/183046a0 . 13622683 . 4653 . 1959Natur.183...46W . 4289861 . free .
- Whelan WH . 1971 . Enzymic explorations of the structures of starch and glycogen . Biochem. J. . 122 . 609 - 622 . 5001952 . 5 . 1176828 . 10.1042/bj1220609.
Notes and References
- A critical role for disproportionating enzyme in starch breakdown is revealed by a knock-out mutation in Arabidopsis. The Plant Journal. 2001-04-01. 1365-313X. 89–100. 26. 1. 10.1046/j.1365-313x.2001.01012.x. Joanna H.. Critchley. Samuel C.. Zeeman. Takeshi. Takaha. Alison M.. Smith. Steven M.. Smith. 11359613. free.
- A cytosolic glucosyltransferase is required for conversion of starch to sucrose in Arabidopsis leaves at night. The Plant Journal. 2004-03-01. 1365-313X. 853–863. 37. 6. 10.1111/j.1365-313X.2003.02012.x. Tansy. Chia. David. Thorneycroft. Andrew. Chapple. Gaëlle. Messerli. Jychian. Chen. Samuel C.. Zeeman. Steven M.. Smith. Alison M.. Smith. 14996213. free.
- Potato D-enzyme Catalyzes the Cyclization of Amylose to Produce Cycloamylose, a Novel Cyclic Glucan. Journal of Biological Chemistry. 1996-02-09. 0021-9258. 2902–2908. 271. 6. 10.1074/jbc.271.6.2902. 8621678. Takeshi. Takaha. Michiyo. Yanase. Hiroki. Takata. Shigetaka. Okada. Steven M.. Smith. free.
