4-Nonylphenylboronic acid explained

4-Nonylphenylboronic acid is a potent and selective inhibitor of the enzyme fatty acid amide hydrolase (FAAH), with an IC50 of 9.1nM, and 870x selectivity for FAAH over the related enzyme MAGL, which it inhibits with an IC50 of 7900nM.[1] It is also a weaker inhibitor of the enzymes endothelial lipase and lipoprotein lipase, with values of 100 nM and 1400 nM respectively.[2]

See also

Notes and References

  1. Minkkilä A, Saario SM, Käsnänen H, Leppänen J, Poso A, Nevalainen T . Discovery of boronic acids as novel and potent inhibitors of fatty acid amide hydrolase . Journal of Medicinal Chemistry . 51 . 22 . 7057–60 . November 2008 . 18983140 . 10.1021/jm801051t .
  2. O'Connell DP, LeBlanc DF, Cromley D, Billheimer J, Rader DJ, Bachovchin WW . Design and synthesis of boronic acid inhibitors of endothelial lipase . Bioorganic & Medicinal Chemistry Letters . 22 . 3 . 1397–401 . February 2012 . 22225633 . 10.1016/j.bmcl.2011.12.043 .

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