4-Nitrobiphenyl Explained

4-Nitrobiphenyl is an organic compound with the formula . It is one of three isomers of nitrobiphenyl and probably the most widely used. It is a precursor to the antioxidant 4-aminobiphenyl. 4-Nitrobiphenyl is readily prepared by nitration of biphenyl.[1] It can also be prepared by cross-coupling reactions.[2]

4-Nitrobiphenyl is commonly invoked as a pollutant.[3] [4]

Notes and References

  1. 10.1021/jo981557o . A Novel Method for the Nitration of Simple Aromatic Compounds . 1998 . Smith . Keith . Musson . Adam . Deboos . Gareth A. . The Journal of Organic Chemistry . 63 . 23 . 8448–8454 .
  2. 10.1021/ja992130h . Highly Active Palladium Catalysts for Suzuki Coupling Reactions . 1999 . Wolfe . John P. . Singer . Robert A. . Yang . Bryant H. . Buchwald . Stephen L. . Journal of the American Chemical Society . 121 . 41 . 9550–9561 .
  3. 10.1002/jat.2980 . Nitroaromatic compounds: Environmental toxicity, carcinogenicity, mutagenicity, therapy and mechanism . 2014 . Kovacic . Peter . Somanathan . Ratnasamy . Journal of Applied Toxicology . 34 . 8 . 810–824 . 24532466 .
  4. 10.3109/03602539009041085 . Metabolism of Nitro-Polycyclic Aromatic Hydrocarbons . 1990 . Fu . Peter P. . Drug Metabolism Reviews . 22 . 2–3 . 209–268 . 2272288 .

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