4-Methoxyestradiol Explained

4-Methoxyestradiol (4-ME2) is an endogenous, naturally occurring methoxylated catechol estrogen and metabolite of estradiol that is formed by catechol O-methyltransferase via the intermediate 4-hydroxyestradiol.^{[1] [2] [3]} It has estrogenic activity similarly to estrone and 4-hydroxyestrone.^[4]

See also

• 2-Methoxyestradiol
• 2-Methoxyestriol
• 2-Methoxyestrone
• 4-Methoxyestrone

External links

• Metabocard for 4-Methoxyestradiol - Human Metabolome Database

Notes and References

1. Web site: Human Metabolome Database: Showing metabocard for 4-Methoxy-17beta-estradiol (HMDB0012782).
2. Book: Anna R. Hemnes. Gender, Sex Hormones and Respiratory Disease: A Comprehensive Guide. 16 December 2015. Humana Press. 978-3-319-23998-9. 32–.
3. Book: Christian Lauritzen. John W. W. Studd. Current Management of the Menopause. 22 June 2005. CRC Press. 978-0-203-48612-2. 378–379.
4. Bhavnani BR, Nisker JA, Martin J, Aletebi F, Watson L, Milne JK . Comparison of pharmacokinetics of a conjugated equine estrogen preparation (premarin) and a synthetic mixture of estrogens (C.E.S.) in postmenopausal women . J. Soc. Gynecol. Investig. . 7 . 3 . 175–83 . 2000 . 10865186 . 10.1016/s1071-5576(00)00049-6.