4-MeO-DMT explained

4-MeO-DMT (4-methoxy-N,N-dimethyltryptamine) is a tryptamine derivative which has some central activity in animal tests similar to that of related psychedelic tryptamine drugs, although with significantly lower potency than either 5-MeO-DMT or 4-hydroxy-DMT (psilocin).^{[1] [2] [3] [4]}

Legality

In the United States 4-MeO-DMT is a Schedule 1 controlled substance as a positional isomer of 5-MeO-DMT.^[5]

See also

• 4-Acetoxy-DMT
• Alexander Shulgin
• 4-MeO-MiPT

Notes and References

1. Glennon RA, Young R, Benington F, Morin RD . Hallucinogens as discriminative stimuli: a comparison of 4-OMe DMT and 5-OMe DMT with their methythio counterparts . Life Sciences . 30 . 5 . 465–7 . February 1982 . 6801410 . 10.1016/0024-3205(82)90463-5.
2. Kline TB, Benington F, Morin RD, Beaton JM . Structure-activity relationships in potentially hallucinogenic N,N-dialkyltryptamines substituted in the benzene moiety . Journal of Medicinal Chemistry . 25 . 8 . 908–13 . August 1982 . 7120280 . 10.1021/jm00350a005.
3. Kline TB, Benington F, Morin RD, Beaton JM, Glennon RA, Domelsmith LN, Houk KN, Rozeboom MD . Structure-activity relationships for hallucinogenic N,N-dialkyltryptamines: photoelectron spectra and serotonin receptor affinities of methylthio and methylenedioxy derivatives . Journal of Medicinal Chemistry . 25 . 11 . 1381–3 . November 1982 . 6815326 . 10.1021/jm00353a021.
4. Nichols DE, Glennon RA. Medicinal Chemistry and Structure-Activity Relationships of Hallucinogens, in Hallucinogens, Neurochemical, Behavioral, and Clinical Perspectives (Raven Press 1984), pp 95-142.
5. Web site: Lists of Scheduling Actions Controlled Substances Regulated Chemical. deadiversion.usdoj.gov. 8 April 2023.