4-Hydroxyestradiol Explained

4-Hydroxyestradiol (4-OHE2), also known as estra-1,3,5(10)-triene-3,4,17β-triol, is an endogenous, naturally occurring catechol estrogen and a minor metabolite of estradiol.^[1] It is estrogenic, similarly to many other hydroxylated estrogen metabolites such as 2-hydroxyestradiol, 16α-hydroxyestrone, estriol (16α-hydroxyestradiol), and 4-hydroxyestrone but unlike 2-hydroxyestrone.^[2]

See also

• Estrogen conjugate
• Lipoidal estradiol

External links

• Metabocard for 4-Hydroxyestradiol - Human Metabolome Database

Notes and References

1. Book: Michael Oettel. Ekkehard Schillinger. Estrogens and Antiestrogens I: Physiology and Mechanisms of Action of Estrogens and Antiestrogens. 6 December 2012. Springer Science & Business Media. 978-3-642-58616-3. 224, 232, 244–245, 249.
2. Bhavnani BR, Nisker JA, Martin J, Aletebi F, Watson L, Milne JK . Comparison of pharmacokinetics of a conjugated equine estrogen preparation (premarin) and a synthetic mixture of estrogens (C.E.S.) in postmenopausal women . J. Soc. Gynecol. Investig. . 7 . 3 . 175–83 . 2000 . 10865186 . 10.1016/s1071-5576(00)00049-6.