4-Hydroxycyclohexanecarboxylate dehydrogenase explained

4-hydroxycyclohexanecarboxylate dehydrogenase
Ec Number:	1.1.1.226
Cas Number:	67272-36-0
Go Code:	0047030

In enzymology, a 4-hydroxycyclohexanecarboxylate dehydrogenase is an enzyme that catalyzes the chemical reaction

trans-4-hydroxycyclohexanecarboxylate + NAD⁺

\rightleftharpoons 4-oxocyclohexanecarboxylate + NADH + H⁺

Thus, the two substrates of this enzyme are trans-4-hydroxycyclohexanecarboxylate and NAD⁺, whereas its 3 products are 4-oxocyclohexanecarboxylate, NADH, and H⁺.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD⁺ or NADP⁺ as acceptor. The systematic name of this enzyme class is trans-4-hydroxycyclohexanecarboxylate:NAD⁺ 4-oxidoreductase. This enzyme is also called trans-4-hydroxycyclohexanecarboxylate dehydrogenase.

References

• Obata H, Uebayasi M, Kaneda T . 1988 . Purification and properties of 4-hydroxycyclohexanecarboxylate dehydrogenase from Corynebacterium cyclohexanicum . Eur. J. Biochem. . 174 . 451–8 . 3292236 . 10.1111/j.1432-1033.1988.tb14119.x . 3 . free .