4-HO-PiPT explained

4-Hydroxy-N-propyl-N-isopropyltryptamine (4-HO-PiPT, Piprocin) is a substituted tryptamine derivative which is claimed to have psychedelic effects.^[1] It acts as a 5-HT_2A receptor agonist, with an EC₅₀ of 13.8 nM and an efficacy of 104.8% (vs 5-HT),^[2] and has been sold as a designer drug, first being identified in 2021 in British Columbia, Canada.^[3]

See also

• 4-HO-DPT
• 4-HO-DiPT
• 4-HO-DSBT
• 4-HO-EiBT
• 4-HO-McPT
• 4-HO-McPeT
• 5-MeO-PiPT
• Ebalzotan
• Propylisopropyltryptamine

Notes and References

1. https://patents.google.com/patent/WO2024042239A1 Morrison J. Glycosylated psilocin derivatives and methods of use. WO 2024/042239A1
2. https://patentscope.wipo.int/search/docs2/pct/WO2023115167/pdf/filename=WO2023115167-PAMPH-20230629-9042.pdf Banister S, Jorgensen W, Jinlong T. Compounds. Patent WO 2023/115167
3. A Report on British Columbia's Unregulated Drug Supply. Drug checking trends across British Columbia, January to December 2021. . Knill A, Tobias S, Matthews J, Ti L . June 2022 . British Columbia Centre on Substance Use .