4-Fluoroaniline Explained

4-Fluoroaniline is an organofluorine compound with the formula . A colorless liquid, it is one of three isomers of fluoroaniline. It is used as a precursor to various potential and real applications.

4-Fluoroaniline can be prepared by the hydrogenation of 4-nitrofluorobenzene.^[1]

It is a common building block in medicinal chemistry and related fields.^[2] For example, it is a precursor to the fungicide fluoroimide or the fentanyl analogue parafluorofentanyl. It has also been evaluated for the production of ligands for homogeneous catalysis.^[3]

Notes and References

1. 10.1126/science.1242005 . Nanoscale Fe₂O₃-Based Catalysts for Selective Hydrogenation of Nitroarenes to Anilines . 2013 . Jagadeesh . Rajenahally V. . Surkus . Annette-Enrica . Junge . Henrik . Pohl . Marga-Martina . Radnik . Jörg . Rabeah . Jabor . Huan . Heming . Schünemann . Volker . Brückner . Angelika . Beller . Matthias . Science . 342 . 6162 . 1073–1076 . 24288327 . 2013Sci...342.1073J . 11780985 .
2. 10.3389/fchem.2019.00253 . free . Synthesis and Biological Evaluation of 4β-N-Acetylamino Substituted Podophyllotoxin Derivatives as Novel Anticancer Agents . 2019 . Wei . Jinbao . Chen . Jinghong . Ju . Peijun . Ma . Le . Chen . Li . Ma . Weidong . Zheng . Tao . Yang . Guangyi . Wang . Yong-Xiang . Frontiers in Chemistry . 7 . 253 . 31106192 . 6491884 . 2019FrCh....7..253W .
3. 10.1021/ja0117581 . Living Polymerization of Ethylene Catalyzed by Titanium Complexes Having Fluorine-Containing Phenoxy−Imine Chelate Ligands . 2002 . Mitani . Makoto . Mohri . Jun-Ichi . Yoshida . Yasunori . Saito . Junji . Ishii . Seiichi . Tsuru . Kazutaka . Matsui . Shigekazu . Furuyama . Rieko . Nakano . Takashi . Tanaka . Hidetsugu . Kojoh . Shin-Ichi . Matsugi . Tomoaki . Kashiwa . Norio . Fujita . Terunori . Journal of the American Chemical Society . 124 . 13 . 3327–3336 . 11916417 .