4-Deoxypyridoxine Explained

4-Deoxypyridoxine is a vitamin B6 antagonist.[1] It may be toxic to developing embryos since it can have negative effects on collagen and elastin during development.[2] The presence of this compound can produce vitamin B6 deficiency, which suppresses the immune system.[3] 4-Deoxypyridoxine lowers vitamin B6 concentration by competitively inhibiting some of the enzymes necessary for the regeneration of vitamin B6.[4] The related immunosuppression can be beneficial in animal models of Trichinella spiralis infections.[5] 4-Deoxypyridoxine has also been described as an inhibitor of sphingosine-1-phosphate lyase.[6] The inhibition of sphingosine-1-phosphate lyase by 4-deoxypyridoxine has been shown to prevent cell death of ex vivo animal pancreatic islets. The use of 4-deoxypyridoxine to prevent stress-induced apoptosis is suggest that the compound, as well as other inhibitors of sphingosine-1-phosphate lyase, could be used to increase the viability of donor pancreatic tissue in the treatment of diabetes.[7]

Notes and References

  1. Coburn SP, Mahuren JD, Schaltenbrand WE, Wostmann BS, Madsen D . Effects of vitamin B-6 deficiency and 4'- deoxypyridoxine on pyridoxal phosphate concentrations, pyridoxine kinase and other aspects of metabolism in the rat . J. Nutr. . 111 . 2 . 391–8 . 1 February 1981. 6257871 . 10.1093/jn/111.2.391 .
  2. Bird TA, Levene CI . The effect of a vitamin B-6 antagonist, 4-deoxypyridoxine, on the cross-linking of collagen in the developing chick embryo . Biochem. J. . 210 . 3 . 633–8 . 1983 . 6135414 . 1154271. 10.1042/bj2100633 .
  3. Trakatellis A, Dimitriadou A, Exindari M . Effect of pyridoxine deficiency on immunological phenomena . Postgrad Med J . 68 . S70–7 . 1992 . Suppl 1 . 1409221. etal.
  4. 34213717 . 2021 . Sheridan . E. . Gillespie . S. . Johnson . C. R. . Lecavalier . L. . Smith . T. . Swiezy . N. . Turner . K. . Pritchett . J. . Mruzek . D. W. . Evans . A. N. . Bearss . K. . Scahill . L. . Using Parent Target Problem Narratives to Evaluate Outcomes in Children with Autism Spectrum Disorder . Research on Child and Adolescent Psychopathology . 49 . 11 . 1527–1535 . 10.1007/s10802-021-00843-8 . 235709478 .
  5. Frydas S, Papaioanou N, Vlemmas I . Vitamin B6-deficient diet plus 4-deoxypyridoxine (4-DPD) reduces the inflammatory response induced by T. spiralis in diaphragm, masseter and heart muscle tissue of mice . Mol. Cell. Biochem. . 197 . 1–2 . 79–85 . 1999 . 10485327 . 10.1023/A:1006958310081. 23457740 . etal.
  6. Weigel. Cynthia. Hüttner. Sören S.. Ludwig. Kristin. Krieg. Nadine. Hofmann. Susann. Schröder. Nathalie H.. Robbe. Linda. Kluge. Stefan. Nierhaus. Axel. Winkler. Martin S.. Rubio. Ignacio. 2020-08-01. S1P lyase inhibition protects against sepsis by promoting disease tolerance via the S1P/S1PR3 axis. eBioMedicine. English. 58. 102898 . 10.1016/j.ebiom.2020.102898. 7381498. 2352-3964. 32711251.
  7. 10.4161/isl.25254 . 4-deoxypyridoxine improves the viability of isolated pancreatic islets ex vivo . 2013 . Lee . Hakmo . Seon Park . Ho . Hee Hong . Shin . Kyung Choi . Ok . Cho . Sung-Dae . Park . Jongwoo . Eun Oh . Ju . Soo Chung . Sung . Jung . Hye Seung . Park . Kyong Soo . Islets . 5 . 3 . 116–121 . 23756681 . 22959354 . free .

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