4-DAMP explained

4-DAMP (1,1-dimethyl-4-diphenylacetoxypiperidinium iodide) is a selective muscarinic acetylcholine receptor (mAChR) M3 antagonist.[1] It is also able to antagonize M1 receptors but "prefers" M3.[2] [3] It competitively binds to the acetylcholine binding site on mAChRs, causing right-ward shift in the dose response curves for mAChR agonists.

Notes and References

  1. Zhu, MH. Sung, IK. Zheng, H. Sung, TS. Britton, FC. O'Driscoll, K. Koh, SD. Sanders, KM. Muscarinic activation of Ca2+-activated Cl- current in interstitial cells of Cajal. J Physiol. 2011. 589. Pt18. 4565–4582. 21768263. 10.1113/jphysiol.2011.211094. 3208225.
  2. Teixeira-Neto, FJ. McDonell, WN. Black, WD. Harris, W and . Grovum, L. Effects of muscarinic receptor antagonists on acetylcholine-induced contractions of jejunal smooth muscle in horses. Journal of Veterinary Pharmacology and Therapeutics. 2012. 35. 4. 313–318. 21859432. 10.1111/j.1365-2885.2011.01330.x.
  3. Greenwood, JM and . Dragunow, M. M3 muscarinic receptors promote cell survival through activation of the extracellular regulated kinase (ERK1/2) pathway. Eur J Pharmacol. 2010. 640. 1–3. 38–45. 20519144. 10.1016/j.ejphar.2010.05.013.

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