4-Cyano-3-(trifluoromethyl)aniline explained

4-Cyano-3-(trifluoromethyl)aniline, also known as 4-amino-2-(trifluoromethyl)benzonitrile, is a cyanated and trifluoromethylated derivative of aniline. It is the starting material in one of the chemical syntheses of the nonsteroidal antiandrogen bicalutamide.^[1]

Notes and References

1. Tucker H, Crook JW, Chesterson GJ . Nonsteroidal antiandrogens. Synthesis and structure-activity relationships of 3-substituted derivatives of 2-hydroxypropionanilides . Journal of Medicinal Chemistry . 31 . 5 . 954–9 . 1988 . 3361581 . 10.1021/jm00400a011.