4-Bromomethcathinone Explained
4-Bromomethcathinone (4-BMC, Brephedrone) is a psychoactive drug and research chemical of the phenethylamine, amphetamine, and cathinone chemical classes. It acts as a serotonin and norepinephrine reuptake inhibitor,[1] [2] but acts more like an antidepressant than a stimulant.[3] Some 4-halogenated cathinones seem to share the selective serotonergic neurotoxicity of their corresponding amphetamine analogues.[4]
Legal status
As of October 2015, 4-BMC is a controlled substance in China.[5] 4-Bromomethcathinone is considered a Schedule 1 substance in Virginia.[6]
See also
Notes and References
- Foley KF, Cozzi NV . Bromine substitution at the ring 3- or 4-position of methcathinone enhances potency at serotonin uptake transporters . Society for Neuroscience Abstracts . 1999 . 25 . 1–2 . 1701 . 678.17 . 2013-07-28 . https://web.archive.org/web/20130907120810/http://www.neurophys.wisc.edu/~cozzi/sfnabs25.html . 2013-09-07 . dead .
- Foley KF, Cozzi NV . Inhibition of transport function and desipramine binding at the human noradrenaline transporter by N-ethylmaleimide and protection by substrate analogs . Naunyn-Schmiedeberg's Archives of Pharmacology . 365 . 6 . 457–461 . June 2002 . 12070759 . 10.1007/s00210-002-0532-3 . 3244808 .
- Foley KF, Cozzi NV . Novel aminopropiophenones as potential antidepressants . Drug Development Research . 2003 . 60 . 4 . 252–260 . 10.1002/ddr.10297 . 84128787 . 2015-09-09 . https://web.archive.org/web/20160306221301/https://ewsd.wiv-isp.be/Publications%20on%20new%20psychoactive%20substances/Mephedrone/Foley2003_methcathinone-analogs.pdf . 2016-03-06 . dead .
- Wojcieszak J, Kuczyńska K, Zawilska JB . Four Synthetic Cathinones: 3-Chloromethcathinone, 4-Chloromethcathinone, 4-Fluoro-α-Pyrrolidinopentiophenone, and 4-Methoxy-α-Pyrrolidinopentiophenone Produce Changes in the Spontaneous Locomotor Activity and Motor Performance in Mice with Varied Profiles . Neurotoxicity Research . 38 . 2 . 536–551 . August 2020 . 32506339 . 7334283 . 10.1007/s12640-020-00227-8 .
- Web site: 关于印发《非药用类麻醉药品和精神药品列管办法》的通知 . China Food and Drug Administration . 27 September 2015 . Chinese . 1 October 2015 . https://web.archive.org/web/20151001222554/http://www.sfda.gov.cn/WS01/CL0056/130753.html . 1 October 2015 . dead .
- Web site: 18VAC110-20-322. Placement of Chemicals in Schedule I. . Commonwealth of Virginia . 2 December 2015 . English . 11 March 2016.