4-(Gamma-L-glutamylamino)butanoyl-(BtrI acyl-carrier protein) monooxygenase explained

4-(gamma-L-glutamylamino)butanoyl-(BtrI acyl-carrier protein) monooxygenase
Ec Number:1.14.14.13

4-(gamma-L-glutamylamino)butanoyl-(BtrI acyl-carrier protein) monooxygenase (btrO (gene)) is an enzyme with systematic name 4-(gamma-L-glutamylamino)butanoyl-(BtrI acyl-carrier protein),FMN:oxygen oxidoreductase (2-hydroxylating).[1] This enzyme catalyses the following chemical reaction

4-(gamma-L-glutamylamino)butanoyl-[BtrI acyl-carrier protein] + FMNH2 + O2

\rightleftharpoons

4-(gamma-L-glutamylamino)-(2S)-2-hydroxybutanoyl-[BtrI acyl-carrier protein] + FMN + H2O

4-(gamma-L-glutamylamino)butanoyl-(BtrI acyl-carrier protein) monooxygenase catalyses a step in the biosynthesis of the side chain of the aminoglycoside antibiotics of the butirosin family.

Notes and References

  1. Li Y, Llewellyn NM, Giri R, Huang F, Spencer JB . Biosynthesis of the unique amino acid side chain of butirosin: possible protective-group chemistry in an acyl carrier protein-mediated pathway . Chemistry & Biology . 12 . 6 . 665–75 . June 2005 . 15975512 . 10.1016/j.chembiol.2005.04.010 . free .

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