4α-Methylfecosterol explained

4α-Methylfecosterol is a metabolic intermediate of sterols made by certain fungis, can be converted to 24-Methylenelophenol by enzyme HYD1, or undergo 4-demethylation to fecosterol.[1] [2]

Notes and References

  1. Kuchta . T . Bartková . K . Kubinec . R . Ergosterol depletion and 4-methyl sterols accumulation in the yeast Saccharomyces cerevisiae treated with an antifungal, 6-amino-2-n-pentylthiobenzothiazole. . Biochemical and Biophysical Research Communications . 30 November 1992 . 189 . 1 . 85–91 . 10.1016/0006-291x(92)91529-y . 1449509.
  2. Kuchta . T . Léka . C . Farkas . P . Bujdáková . H . Belajová . E . Russell . NJ . Inhibition of sterol 4-demethylation in Candida albicans by 6-amino-2-n-pentylthiobenzothiazole, a novel mechanism of action for an antifungal agent. . Antimicrobial Agents and Chemotherapy . July 1995 . 39 . 7 . 1538–41 . 10.1128/aac.39.7.1538 . 7492100. 162777 . free .

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