4'-demethylrebeccamycin synthase explained

4′--demethylrebeccamycin synthase
Ec Number:4.3.3.5

4′-Demethylrebeccamycin synthase (EC 4.3.3.5, arcyriaflavin A N-glycosyltransferase, RebG) is an enzyme with systematic name 4′-demethylrebeccamycin D-glucose-lyase.[1] [2] It catalyses the following chemical reaction

4′-O-demethylrebeccamycin + H2O

\rightleftharpoons

dichloro-arcyriaflavin A + β-D-glucose

This enzyme catalyses a step in the biosynthesis of rebeccamycin.

Notes and References

  1. Ohuchi T, Ikeda-Araki A, Watanabe-Sakamoto A, Kojiri K, Nagashima M, Okanishi M, Suda H . Cloning and expression of a gene encoding N-glycosyltransferase (ngt) from Saccarothrix aerocolonigenes ATCC39243 . The Journal of Antibiotics . 53 . 4 . 393–403 . April 2000 . 10866221 . 10.7164/antibiotics.53.393 . free .
  2. Zhang C, Albermann C, Fu X, Peters NR, Chisholm JD, Zhang G, Gilbert EJ, Wang PG, Van Vranken DL, Thorson JS . RebG- and RebM-catalyzed indolocarbazole diversification . ChemBioChem . 7 . 5 . 795–804 . May 2006 . 16575939 . 10.1002/cbic.200500504 .

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