4',7-Dihydroxyflavone Explained

4′,7-Dihydroxyflavone is a flavone. It is found in Medicago truncatula in relation with the root nodulation symbiont Sinorhizobium meliloti^[1] or in seeds of Sophora viciifolia.^[2]

Like many other flavonoids, 4′,7-dihydroxyflavone has been found to possess activity at opioid receptors in vitro.^[3] Specifically, it acts as an antagonist of the μ-opioid receptor and, with lower affinity, of the κ- and δ-opioid receptors.

See also

• Pratol (7-hydroxy-4′-methoxyflavone) is the O-methylated form of the molecule.

Notes and References

1. 10.1111/j.1365-313X.2008.03676.x. 18786000. Flavones and flavonols play distinct critical roles during nodulation of Medicago truncatula by Sinorhizobium meliloti. 2009. Zhang. Juan. Subramanian. Senthil. Stacey. Gary. Yu. Oliver. The Plant Journal. 57. 171–83. 1. free.
2. 9206257. Chinese. 1996. Wang. X. Li. J. Wei. L. Ohmiya. S. Flavone constituents in the seeds of Sophora vicii folia Hance. 21. 3. 165–6, 191. Zhongguo Zhong Yao Za Zhi = Zhongguo Zhongyao Zazhi = China Journal of Chinese Materia Medica.
3. Katavic PL, Lamb K, Navarro H, Prisinzano TE . Flavonoids as opioid receptor ligands: identification and preliminary structure-activity relationships . J. Nat. Prod. . 70 . 8 . 1278–82 . August 2007 . 17685652 . 2265593 . 10.1021/np070194x .