3beta(or 20alpha)-hydroxysteroid dehydrogenase explained

3β(or 20α)-hydroxysteroid dehydrogenase
Ec Number:	1.1.1.210
Cas Number:	82869-26-9
Go Code:	0047024

In enzymology, a 3-β(or 20-α)-hydroxysteroid dehydrogenase is an enzyme that catalyzes the chemical reaction

5α-androstan-3β,17β-diol + NADP⁺

\rightleftharpoons 17β-hydroxy-5α-androstan-3-one + NADPH + H⁺

This enzyme possesses the combined activities of the 3-β-hydroxysteroid dehydrogenase/Δ-5-4 isomerase and 20-α-hydroxysteroid dehydrogenase enzymes.^[1]

Notes and References

1. Sharaf MA, Sweet F . Dual activity at an enzyme active site: 3 beta,20 alpha-hydroxysteroid oxidoreductase from fetal blood . Biochemistry . 21 . 19 . 4615–20 . September 1982 . 6958329 . 10.1021/bi00262a016.