3alpha(17beta)-hydroxysteroid dehydrogenase (NAD+) explained

3-alpha(17-beta)-hydroxysteroid dehydrogenase (NAD^+)
Ec Number:	1.1.1.239
Cas Number:	126469-82-7
Go Code:	0047035

In enzymology, a 3alpha(17beta)-hydroxysteroid dehydrogenase (NAD⁺) is an enzyme that catalyzes the chemical reaction:

testosterone + NAD⁺

\rightleftharpoons androst-4-ene-3,17-dione + NADH + H⁺

Thus, the two substrates of this enzyme are testosterone and NAD⁺, whereas its 3 products are androst-4-ene-3,17-dione, NADH, and H⁺.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD⁺ or NADP⁺ as acceptor. The systematic name of this enzyme class is 3alpha(or 17beta)-hydroxysteroid:NAD⁺ oxidoreductase. Other names in common use include 3alpha,17beta-hydroxy steroid dehydrogenase, 3alpha(17beta)-HSD, and 3alpha(17beta)-hydroxysteroid dehydrogenase (NAD⁺). This enzyme participates in androgen and estrogen metabolism.

See also

• 3α-Hydroxysteroid dehydrogenase

References

• Ohmura M, Hara A, Nakagawa M, Sawada H . 1990 . Demonstration of 3α(17β)-hydroxysteroid dehydrogenase distinct from 3α-hydroxysteroid dehydrogenase in hamster liver . Biochem. J. . 266 . 583–9 . 2317205 . 2 . 1131171 .