| 3-α,7-α-Dihydroxy-5-β-cholestanate—CoA ligase | |
| Ec Number: | 6.2.1.28 |
| Cas Number: | 118732-03-9 |
| Go Code: | 0047476 |
In enzymology, a 3α,7α-dihydroxy-5β-cholestanate—CoA ligase is an enzyme that catalyzes the chemical reaction
ATP + (25R)-3alpha,7alpha-dihydroxy-5beta-cholestan-26-oate + CoA
\rightleftharpoons
The 3 substrates of this enzyme are ATP, (25R)-3alpha,7alpha-dihydroxy-5beta-cholestan-26-oate, and CoA, whereas its 3 products are AMP, diphosphate, and (25R)-3alpha,7alpha-dihydroxy-5beta-cholestanoyl-CoA.
This enzyme belongs to the family of ligases, specifically those forming carbon-sulfur bonds as acid-thiol ligases. The systematic name of this enzyme class is (25R)-3alpha,7alpha-dihydroxy-5beta-cholestan-26-oate:CoA ligase (AMP-forming). Other names in common use include 3alpha,7alpha-dihydroxy-5beta-cholestanoyl coenzyme A synthetase, DHCA-CoA ligase, and 3alpha,7alpha-dihydroxy-5beta-cholestanate:CoA ligase (AMP-forming). This enzyme participates in bile acid biosynthesis.