3C-DFE explained

3C-DFE is a lesser-known psychedelic drug, which is a fluorinated derivative of 3C-E. It was first synthesised by Daniel Trachsel in 2002,^{[1] [2]} and has been reported as showing similar psychedelic activity to related compounds, with a dose range of around 20–40 mg and a duration of approximately 10 hours.^[3] Despite its reported psychedelic activity, binding studies in vitro showed 3C-DFE to have a surprisingly weak binding affinity of 2695 nM at 5-HT_2A with negligible affinity at 5-HT_2C,^[3] making it only slightly higher affinity than mescaline, despite its higher potency in vivo.

See also

• 2C-TFE
• Escaline
• DOTFM
• 2C-T-21
• 2C-T-21.5
• 2C-T-28
• 3C-P
• Trifluoromescaline

Notes and References

1. 10.1002/1522-2675(200209)85:9<3019::AID-HLCA3019>3.0.CO;2-4. 2002. Trachsel. Daniel. Helvetica Chimica Acta. 85. 9. 3019–3026 . Synthese von neuen (Phenylalkyl)aminen zur Untersuchung von Struktur-Aktivitätsbeziehungen, Mitteilung 1, Mescalin Derivate.
2. 10.1002/dta.413. 22374819. Fluorine in psychedelic phenethylamines. Drug Testing and Analysis. 4. 7–8. 577–90. 2012. Trachsel. Daniel.
3. Book: Daniel Trachsel, David Lehmann and Christoph Enzensperger . Phenethylamine Von der Struktur zur Funktion . Nachtschatten Verlag AG . 2013 . 978-3-03788-700-4.