3-oxoadipyl-CoA thiolase explained
3-oxoadipyl-CoA thiolase |
Ec Number: | 2.3.1.174 |
In enzymology, a 3-oxoadipyl-CoA thiolase is an enzyme that catalyzes the chemical reaction
succinyl-CoA + acetyl-CoA
CoA + 3-oxoadipyl-CoA
Thus, the two substrates of this enzyme are succinyl-CoA and acetyl-CoA, whereas its two products are CoA and 3-oxoadipyl-CoA.
This enzyme belongs to the family of transferases, specifically those acyltransferases transferring groups other than aminoacyl groups. The systematic name of this enzyme class is succinyl-CoA:acetyl-CoA C-succinyltransferase. This enzyme participates in benzoate degradation via hydroxylation.
3-Oxoadipyl-CoA thiolase belongs to the thiolase family of enzymes.
References
- Kaschabek SR, Kuhn B, Muller D, Schmidt E, Reineke W . 2002 . Degradation of Aromatics and Chloroaromatics by Pseudomonas sp. Strain B13: Purification and Characterization of 3-Oxoadipate:Succinyl-Coenzyme A (CoA) Transferase and 3-Oxoadipyl-CoA Thiolase . J. Bacteriol. . 184 . 207–15 . 11741862 . 10.1128/JB.184.1.207-215.2002 . 1 . 134768 .
- Gobel M, Kassel-Cati K, Schmidt E, Reineke W . 2002 . Degradation of Aromatics and Chloroaromatics by Pseudomonas sp. Strain B13: Cloning, Characterization, and Analysis of Sequences Encoding 3-Oxoadipate:Succinyl-Coenzyme A (CoA) Transferase and 3-Oxoadipyl-CoA Thiolase . J. Bacteriol. . 184 . 216–23 . 11741863 . 10.1128/JB.184.1.216-223.2002 . 1 . 134769 .