Beta-ketoacyl-ACP synthase I explained

3-oxoacyl-[acyl-carrier-protein] synthase I
Ec Number:	2.3.1.41
Cas Number:	9077-10-5
Go Code:	0004315

In enzymology, a beta-ketoacyl-acyl-carrier-protein synthase I is an enzyme that catalyzes the chemical reaction

an acyl-acyl-carrier-protein + malonyl-acyl-carrier-protein

\rightleftharpoons a 3-oxoacyl-acyl-carrier-protein + CO₂ + acyl-carrier-protein

Thus, the two substrates of this enzyme are acyl-acyl-carrier-protein and malonyl-acyl-carrier-protein, whereas its 3 products are 3-oxoacyl-acyl-carrier-protein, CO₂, and acyl carrier protein. This enzyme participates in fatty acid biosynthesis.This enzyme belongs to the family of transferases, specifically those acyltransferases transferring groups other than aminoacyl groups.

Nomenclature

The systematic name of this enzyme class is acyl-[acyl-carrier-protein]:malonyl-[acyl-carrier-protein] C-acyltransferase (decarboxylating).

Other names in common use include:

• beta-ketoacyl-ACP synthase I,
• beta-ketoacyl synthetase,
• beta-ketoacyl-ACP synthetase,
• beta-ketoacyl-acyl carrier protein synthetase,
• beta-ketoacyl-[acyl carrier protein] synthase,
• beta-ketoacylsynthase,
• condensing enzyme (CE),
• 3-ketoacyl-acyl carrier protein synthase,
• fatty acid condensing enzyme,
• acyl-malonyl(acyl-carrier-protein)-condensing enzyme,
• acyl-malonyl acyl carrier protein-condensing enzyme,
• beta-ketoacyl acyl carrier protein synthase,
• 3-oxoacyl-[acyl-carrier-protein] synthase,
• 3-oxoacyl:ACP synthase I,
• KASI,
• KAS I,
• FabF1, and
• FabB.

References

• Book: Alberts AW, Majerus PW, Vagelos PR . Acetyl-CoA acyl carrier protein transacylase . 1969 . Lipids . 14 . 50 - 53 . 10.1016/S0076-6879(69)14009-4 . Methods in Enzymology . 978-0-12-181871-5 . https://archive.org/details/lipids0014unse/page/50 .
• Book: Prescott DJ, Vagelos PR . Advances in Enzymology and Related Areas of Molecular Biology . Acyl carrier protein . 36 . 269–311 . 1972 . 4561013 . 10.1002/9780470122815.ch8 . 9780470122815 .
• Toomey RE, Wakil SJ . Studies on the mechanism of fatty acid synthesis. XVI. Preparation and general properties of acyl-malonyl acyl carrier protein-condensing enzyme from Escherichia coli . The Journal of Biological Chemistry . 241 . 5 . 1159–65 . Mar 1966 . 10.1016/S0021-9258(18)96816-X . free . 5327099 .
• D'Agnolo G, Rosenfeld IS, Vagelos PR . Multiple forms of beta-ketoacyl-acyl carrier protein synthetase in Escherichia coli . The Journal of Biological Chemistry . 250 . 14 . 5289–94 . Jul 1975 . 10.1016/S0021-9258(19)41179-4 . free . 237914 .
• Garwin JL, Klages AL, Cronan JE . Structural, enzymatic, and genetic studies of beta-ketoacyl-acyl carrier protein synthases I and II of Escherichia coli . The Journal of Biological Chemistry . 255 . 24 . 11949–56 . Dec 1980 . 10.1016/S0021-9258(19)70226-9 . free . 7002930 .
• Wang H, Cronan JE . Functional replacement of the FabA and FabB proteins of Escherichia coli fatty acid synthesis by Enterococcus faecalis FabZ and FabF homologues . The Journal of Biological Chemistry . 279 . 33 . 34489–95 . Aug 2004 . 15194690 . 10.1074/jbc.M403874200 . free .
• Neidhardt, F.C. (Ed.), Escherichia coli and Salmonella: Cellular and Molecular Biology, 2nd ed., vol. 1, ASM Press, Washington, DC, 1996, p. 612-636.