3-oxoacyl-(acyl-carrier-protein) reductase explained

3-oxoacyl-[acyl-carrier-protein] reductase
Ec Number:	1.1.1.100
Cas Number:	37250-34-3
Go Code:	0004316
Width:	270

In enzymology, a 3-oxoacyl-[acyl-carrier-protein] reductase is an enzyme that catalyzes the chemical reaction

\rightleftharpoons (3R)-3-hydroxyacyl-[acyl-carrier-protein](ACP) + NADP⁺

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group as hydride donor with NAD⁺ or NADP⁺ as hydride acceptor. The systematic name of this enzyme class is (3R)-3-hydroxyacyl-[acyl-carrier-protein]:NADP⁺ oxidoreductase. Other names in common use include beta-ketoacyl-[acyl-carrier protein](ACP) reductase, beta-ketoacyl acyl carrier protein (ACP) reductase, beta-ketoacyl reductase, beta-ketoacyl thioester reductase, beta-ketoacyl-ACP reductase, beta-ketoacyl-acyl carrier protein reductase, 3-ketoacyl acyl carrier protein reductase, 3-ketoacyl ACP reductase, NADPH-specific 3-oxoacyl-[acylcarrier protein]reductase, and 3-oxoacyl-[ACP]reductase. This enzyme participates in fatty acid biosynthesis and polyunsaturated fatty acid biosynthesis.

Structural studies

As of late 2007, 21 structures have been solved for this class of enzymes, with PDB accession codes,,,,,,,,,,,,,,,,,,,, and .

References

• Book: Prescott DJ, Vagelos PR . Advances in Enzymology and Related Areas of Molecular Biology . Acyl Carrier Protein . 1972 . Advances in Enzymology - and Related Areas of Molecular Biology . 36 . 269 - 311 . 4561013 . 10.1002/9780470122815.ch8. 9780470122815 .
• Shimakata T, Stumpf PK . 1982 . Purification and characterizations of beta-Ketoacyl-[acyl-carrier-protein] reductase, beta-hydroxyacyl-[acylcarrier-protein] dehydrase, and enoyl-[acyl-carrier-protein] reductase from Spinacia oleracea leaves . Arch. Biochem. Biophys. . 218 . 77 - 91 . 6756317 . 1 . 10.1016/0003-9861(82)90323-X.
• Toomey RE, Wakil SJ . 1966 . Studies on the mechanism of fatty acid synthesis. XV. Preparation and general properties of beta-ketoacyl acyl carrier protein reductase from Escherichia coli . Biochim. Biophys. Acta . 116 . 189 - 97 . 4381013 . 2 . 10.1016/0005-2760(66)90001-4.