3-MeO-PCE explained

Iupac Name:N-Ethyl-1-(3-methoxyphenyl)cyclohexan-1-amine
Legal Uk:Class B
Legal De:NpSG
Legal Status:Illegal in Sweden and Switzerland
Cas Number:1364933-80-1
Unii:PX6CYK9I4H
Pubchem:57461569
Chemspiderid:58191438
Synonyms:3-MeO-PCE; Methoxieticyclidine
C:15
H:23
N:1
O:1
Smiles:CCNC1(CCCCC1)C2=CC(=CC=C2)OC
Stdinchi:1S/C15H23NO/c1-3-16-15(10-5-4-6-11-15)13-8-7-9-14(12-13)17-2/h7-9,12,16H,3-6,10-11H2,1-2H3
Stdinchikey:OFGOOZLOGUNDFS-UHFFFAOYSA-N

3-Methoxyeticyclidine (3-MeO-PCE), also known as methoxieticyclidine, is a dissociative anesthetic that is qualitatively similar to PCE and PCP[1] and has been sold online as a designer drug.[2] [3] [4]

On October 18, 2012, the Advisory Council on the Misuse of Drugs in the United Kingdom released a report about methoxetamine, saying that the "harms of methoxetamine are commensurate with Class B of the Misuse of Drugs Act (1971)", despite the fact that the act does not classify drugs based on harm. The report went on to suggest that all analogues of methoxetamine should also become class B drugs and suggested a catch-all clause covering both existing and unresearched arylcyclohexamines, including 3-MeO-PCE.[5]

This report also described the receptor binding profile of methoxetamine and three additional dissociatives 3-MeO-PCP, 4-MeO-PCP, and 3-MeO-PCE, showing them to have significant affinity for the PCP site of the NMDA receptor (NMDAR) and was later published in more detail.[6]

3-MeO-PCE has Ki values of 61 nM for the NMDAR, 743 nM for the dopamine transporter, 2097 nM for the histamine H2 receptor, 964 nM for the alpha-2A adrenergic receptor, 115 nM for the serotonin transporter, 4519 nM for the σ1 receptor, and 525 nM for the σ2 receptor.[6]

Legal status

3-MeO-PCE is banned in Sweden[7] [8] and Switzerland.[9]

As per Chile's Ley de drogas, aka Ley 20000,[10] all esters and ethers of PCE are illegal. As 3-MeO-PCE is an ether of PCE, it is thus illegal.

See also

Notes and References

  1. Morris H, Wallach J . From PCP to MXE: a comprehensive review of the non-medical use of dissociative drugs . Drug Testing and Analysis . 6 . 7–8 . 614–32 . July–August 2014 . 24678061 . 10.1002/dta.1620 .
  2. De Paoli G, Brandt SD, Wallach J, Archer RP, Pounder DJ . From the street to the laboratory: analytical profiles of methoxetamine, 3-methoxyeticyclidine and 3-methoxyphencyclidine and their determination in three biological matrices . Journal of Analytical Toxicology . 37 . 5 . 277–83 . June 2013 . 23552616 . 10.1093/jat/bkt023 . free .
  3. Wallach J, Colestock T, Cicali B, Elliott SP, Kavanagh PV, Adejare A, Dempster NM, Brandt SD . 6 . Syntheses and analytical characterizations of N-alkyl-arylcyclohexylamines . Drug Testing and Analysis . 8 . 8 . 801–15 . August 2016 . 26360516 . 10.1002/dta.1861 . 1599386 .
  4. Web site: 3-MeO-PCE. New Synthetic Drugs Database. 2016-08-27. https://web.archive.org/web/20160729183729/http://nsddb.eu/substance/296/. 2016-07-29. dead.
  5. Web site: Advisory Council on the Misuse of Drugs (ACMD) Methoxetamine report, 2012. 18 October 2012. UK Home Office.
  6. Bryan Roth . Roth BL, Gibbons S, Arunotayanun W, Huang XP, Setola V, Treble R, Iversen L . The ketamine analogue methoxetamine and 3- and 4-methoxy analogues of phencyclidine are high affinity and selective ligands for the glutamate NMDA receptor . PLOS ONE . 8 . 3 . e59334 . March 2013 . 23527166 . 3602154 . 10.1371/journal.pone.0059334 . 2013PLoSO...859334R . free .
  7. Web site: Elva nya ämnen klassas som narkotika eller hälsofarlig vara. Folkhälsomyndigheten. 28 June 2018. sv.
  8. Web site: Riksdagsförvaltningen. Förordning (1992:1554) om kontroll av narkotika. riksdagen.se. sv.
  9. Web site: Verordnung des EDI vom 30. Mai 2011 über die Verzeichnisse der Betäubungsmittel, psychotropen Stoffe, Vorläuferstoffe und Hilfschemikalien (Betäubungsmittelverzeichnisverordnung, BetmVV-EDI). Der Bundesrat. de.
  10. Web site: SUSTITUYE LA LEY Nº 19.366, QUE SANCIONA EL TRAFICO ILICITO DE ESTUPEFACIENTES Y SUSTANCIAS SICOTROPICAS . Bibloteca Del Congreso Nacional . 22 October 2015 . es . 6 February 2018.

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