3-Methoxyamphetamine Explained
meta-Methoxyamphetamine[1] (MMA), also known as 3-methoxyamphetamine (3-MA), is a stimulant drug from the amphetamine family. It has similar effects in animal drug discrimination tests to the more widely known derivative 4-methoxyamphetamine (PMA),[2] although with a slightly different ratio of monoamine release, being a combined serotonin, dopamine, and norepinephrine releasing agent rather than a fairly selective serotonin releaser like PMA.[3] [4] 3-Methoxyamphetamine has similarly appeared on the illicit market as a designer drug alternative to MDMA, although far more rarely than its infamous positional isomer.[5] It produces gepefrine, a cardiac stimulant, as one of its major metabolites.[6]
See also
Notes and References
- GB . 1527479 . Acid Addition Salts of D-(+)-1-(3-Hydroxyphenyl)-2-Aminopropane and Their Manufacture and Use .
- Glennon RA, Young R, Hauck AE . Structure-activity studies on methoxy-substituted phenylisopropylamines using drug discrimination methodology . Pharmacology, Biochemistry, and Behavior . 22 . 5 . 723–9 . May 1985 . 3839309 . 10.1016/0091-3057(85)90520-9 . 22341227 .
- Tseng LF, Menon MK, Loh HH . Comparative actions of monomethoxyamphetamines on the release and uptake of biogenic amines in brain tissue . The Journal of Pharmacology and Experimental Therapeutics . 197 . 2 . 263–71 . May 1976 . 1271280 . Horace Loh .
- Menon MK, Tseng LF, Loh HH . Pharmacological evidence for the central serotonergic effects of monomethoxyamphetamines . The Journal of Pharmacology and Experimental Therapeutics . 197 . 2 . 272–9 . May 1976 . 946817 .
- Dal Cason TA . A re-examination of the mono-methoxy positional ring isomers of amphetamine, methamphetamine and phenyl-2-propanone . Forensic Science International . 119 . 2 . 168–94 . June 2001 . 11376983 . 10.1016/S0379-0738(00)00425-4 .
- Midha KK, Cooper JK, Bailey K, Hubbard JW . The metabolism of 3-methoxyamphetamine in dog, monkey and man . Xenobiotica; the Fate of Foreign Compounds in Biological Systems . 11 . 2 . 137–46 . February 1981 . 6894510 . 10.3109/00498258109045284 .