3-Iodophenol Explained

3-Iodophenol (m-iodophenol) is an aromatic organic compound. 3-Iodophenol participates in a variety of coupling reactions in which the iodide substituent is displaced.[1] Well cited examples include thiolate[2] and amine nucleophiles.[3]

3-Iodophenol can be prepared by oxidative decarboxylation of 3-iodobenzoic acid:[4]

Cited sources

Notes and References

  1. Web site: 3-Iodophenol. .
  2. 10.1021/ol0266673. A General, Efficient, and Inexpensive Catalyst System for the Coupling of Aryl Iodides and Thiols . 2002 . Kwong . Fuk Yee . Buchwald . Stephen L. . Organic Letters . 4 . 20 . 3517–3520 . 12323058 .
  3. 10.1021/ja077074w. Highly Reactive, General and Long-Lived Catalysts for Palladium-Catalyzed Amination of Heteroaryl and Aryl Chlorides, Bromides, and Iodides: Scope and Structure–Activity Relationships . 2008 . Shen . Qilong . Ogata . Tokutaro . Hartwig . John F. . Journal of the American Chemical Society . 130 . 20 . 6586–6596 . 18444639 . 2822544 .
  4. 10.1021/jacs.2c07529. Simple and Practical Conversion of Benzoic Acids to Phenols at Room Temperature . 2022 . Xiong . Wenzhang . Shi . Qiu . Liu . Wenbo H. . Journal of the American Chemical Society . 144 . 34 . 15894–15902 . 35997485 . 251742827 .

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