3-hydroxypropionyl-CoA synthase explained

3-Hydroxypropionyl-CoA synthase
Ec Number:	6.2.1.36

3-Hydroxypropionyl-CoA synthase (3-hydroxypropionyl-CoA synthetase (AMP-forming), 3-hydroxypropionate-CoA ligase) is an enzyme with systematic name hydroxypropionate:CoA ligase (AMP-forming).^{[1] [2]} This enzyme catalyses the following chemical reaction

3-hydroxypropionate + ATP + CoA

\rightleftharpoons 3-hydroxypropionyl-CoA + AMP + diphosphate

This enzyme catalyses a step in the 3-hydroxypropionate/4-hydroxybutyrate cycle.

Notes and References

1. Berg IA, Kockelkorn D, Buckel W, Fuchs G . A 3-hydroxypropionate/4-hydroxybutyrate autotrophic carbon dioxide assimilation pathway in Archaea . Science . 318 . 5857 . 1782–6 . December 2007 . 18079405 . 10.1126/science.1149976 .
2. Alber BE, Kung JW, Fuchs G . 3-Hydroxypropionyl-coenzyme A synthetase from Metallosphaera sedula, an enzyme involved in autotrophic CO2 fixation . Journal of Bacteriology . 190 . 4 . 1383–9 . February 2008 . 18165310 . 2238213 . 10.1128/JB.01593-07 .