3-hydroxypimeloyl-CoA dehydrogenase explained

3-hydroxypimeloyl-CoA dehydrogenase
Ec Number:	1.1.1.259
Go Code:	0018464

In enzymology, a 3-hydroxypimeloyl-CoA dehydrogenase is an enzyme that catalyzes the chemical reaction

3-hydroxypimeloyl-CoA + NAD⁺

\rightleftharpoons 3-oxopimeloyl-CoA + NADH + H⁺

Thus, the two substrates of this enzyme are 3-hydroxypimeloyl-CoA and NAD⁺, whereas its 3 products are 3-oxopimeloyl-CoA, NADH, and H⁺.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD⁺ or NADP⁺ as acceptor. The systematic name of this enzyme class is 3-hydroxypimeloyl-CoA:NAD⁺ oxidoreductase. This enzyme participates in benzoate degradation via coa ligation.

References

• Harwood CS, Gibson J . 1997 . Shedding light on anaerobic benzene ring degradation: a process unique to prokaryotes? . J. Bacteriol. . 179 . 301 - 9 . 8990279 . 2 . 178697 .