3-Hydroxyoctanoic acid explained

3-Hydroxyoctanoic acid is a beta-hydroxy acid that is naturally produced in humans, other animals, and plants.

3-Hydroxyoctanoic acid is the primary endogenous agonist of hydroxycarboxylic acid receptor 3 (HCA3), a G protein-coupled receptor protein which is encoded by the human gene HCAR3.[1] [2] In plants, signalling chemical emitted by the orchid Cymbidium floribundum and recognized by Japanese honeybees (Apis cerana japonica).[3]

Notes and References

  1. International Union of Basic and Clinical Pharmacology. LXXXII: Nomenclature and Classification of Hydroxy-carboxylic Acid Receptors (GPR81, GPR109A, and GPR109B) . Pharmacological Reviews . 63 . 2 . 269–90 . June 2011 . 21454438 . 10.1124/pr.110.003301 . Offermanns . S . Colletti . S. L . Lovenberg . T. W . Semple . G . Wise . A . Ijzerman . A. P . free .
  2. S. . Offermanns . S. L. . Colletti . A. P. . IJzerman . T. W. . Lovenberg . G. . Semple . A. . Wise . M. G. . Waters . ((CGTP Collaborators)) . Hydroxycarboxylic acid receptors . IUPHAR/BPS Guide to Pharmacology . International Union of Basic and Clinical Pharmacology . 13 July 2018.
  3. 23387843. 2013. Sugahara. M. Izutsu. K. Nishimura. Y. Sakamoto. F. Oriental orchid (Cymbidium floribundum) attracts the Japanese honeybee (Apis cerana japonica) with a mixture of 3-hydroxyoctanoic acid and 10-hydroxy- (E)-2-decenoic acid. 30. 2. 99–104. 10.2108/zsj.30.99. Zoological Science. 45520680.

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