3-hydroxybenzoate—CoA ligase explained

3-Hydroxybenzoate—CoA ligase
Ec Number:	6.2.1.37

3-Hydroxybenzoate—CoA ligase (3-hydroxybenzoyl-CoA synthetase, 3-hydroxybenzoate-coenzyme A ligase (AMP-forming), 3-hydroxybenzoyl coenzyme A synthetase, 3-hydroxybenzoyl-CoA ligase) is an enzyme with systematic name 3-hydroxybenzoate:CoA ligase (AMP-forming).^[1] This enzyme catalyses the following chemical reaction

ATP + 3-hydroxybenzoate + CoA

\rightleftharpoons AMP + diphosphate + 3-hydroxybenzoyl-CoA

The enzyme works equally well with 4-hydroxybenzoate.

Notes and References

1. Laempe D, Jahn M, Breese K, Schägger H, Fuchs G . Anaerobic metabolism of 3-hydroxybenzoate by the denitrifying bacterium Thauera aromatica . Journal of Bacteriology . 183 . 3 . 968–79 . February 2001 . 11208796 . 94965 . 10.1128/jb.183.3.968-979.2001 .