3-Hydroxyaspartic acid explained

3-Hydroxyaspartic acid (three letter abbreviation: Hya) also known as beta-hydroxyaspartic acid is derivative of aspartic acid which has been hydroxylated at position-3. The adjacent image shows L-threo-3-Hydroxyaspartate. The conjugated acid of 3-hydroxyaspartic acid is 3-hydroxyaspartate.

Structure

Similarly to proteinogenic isoleucine and threonine, 3-hydroxyaspartic acid contains two chiral centers. As such, it can exist in 4 stereoisomers, which form two pairs of enantiomers.

Function

The Hya amino acid residue is sometimes contained in EGF-like domains such as Vitamin K-dependent coagulation plasma proteins including protein C.^[1]

D-threo-3-Hydroxyaspartate is a part of the siderophore ornibactin.^[2]

See also

• Epidermal growth factor (EGF)
• Vitamin K-dependent protein

Notes and References

1. Book: gamma-Glutamate and beta-hydroxyaspartate in proteins . Castellino FJ, Ploplis VA, Zhang L . 2008 . 978-1-58829-719-8 . Methods Mol. Biol. . 446 . 85–94 . Γ-Glutamate and β–Hydroxyaspartate in Proteins . 10.1007/978-1-60327-084-7_6 . 18373251.
2. Stephan . Holger . Freund . Stefan . Beck . Werner . Jung . Günther . Meyer . Jean-Marie . Winkelmann . Günther . 1993-06-01 . Ornibactins—a new family of siderophores from Pseudomonas . Biometals . en . 6 . 2 . 93–100 . 10.1007/BF00140109 . 1572-8773.