3-hydroxyanthranilate oxidase explained

3-hydroxyanthranilate oxidase
Ec Number:	1.10.3.5
Cas Number:	37256-53-4
Go Code:	0047561

In enzymology, a 3-hydroxyanthranilate oxidase (also called 3-HAO) is an enzyme that catalyzes the chemical reaction:^[1]

3-hydroxyanthranilate + O₂

\rightleftharpoons 6-imino-5-oxocyclohexa-1,3-dienecarboxylate + H₂O₂

Thus, the two substrates of this enzyme are 3-hydroxyanthranilate and O₂, whereas its two products are 6-imino-5-oxocyclohexa-1,3-dienecarboxylate and H₂O₂.

This enzyme belongs to the family of oxidoreductases, specifically those acting on diphenols and related substances as donor with oxygen as acceptor. The systematic name of this enzyme class is 3-hydroxyanthranilate:oxygen oxidoreductase. This enzyme is also called 3-hydroxyanthranilic acid oxidase.

References

• ((Morgan LR Jr)), Weimorts DM, Aubert CC . 1965 . Oxidation Of 3-hydroxyanthranilic acid by a soluble liver fraction from poikilothermic vertebrates . Biochim. Biophys. Acta . 100 . 393–402 . 14347936 . 10.1016/0304-4165(65)90008-5 .

Notes and References

1. Vécsei. L. Szalárdy. L. Fülöp. F. Toldi. J. Kynurenines in the CNS: recent advances and new questions.. Nature Reviews. Drug Discovery. January 2013. 12. 1. 64–82. 10.1038/nrd3793. 23237916.