3-dehydro-L-gulonate-6-phosphate decarboxylase explained

3-dehydro-L-gulonate-6-phosphate decarboxylase
Ec Number:	4.1.1.85

The enzyme 3-dehydro-L-gulonate-6-phosphate decarboxylase catalyzes the chemical reaction

3-dehydro-L-gulonate 6-phosphate + H⁺

\rightleftharpoons L-xylulose 5-phosphate + CO₂

This enzyme belongs to the family of lyases, specifically the carboxy-lyases, which cleave carbon-carbon bonds. The systematic name of this enzyme class is 3-dehydro-L-gulonate-6-phosphate carboxy-lyase (L-xylulose-5-phosphate-forming). Other names in common use include 3-keto-L-gulonate 6-phosphate decarboxylase, UlaD, SgaH, SgbH, KGPDC, and 3-dehydro-L-gulonate-6-phosphate carboxy-lyase. This enzyme participates in pentose and glucuronate interconversions and ascorbate and aldarate metabolism.

References

• Yew WS, Gerlt JA . Utilization of L-ascorbate by Escherichia coli K-12: assignments of functions to products of the yjf-sga and yia-sgb operons . Journal of Bacteriology . 184 . 1 . 302–6 . January 2002 . 11741871 . 134747 . 10.1128/JB.184.1.302-306.2002 .
• Wise E, Yew WS, Babbitt PC, Gerlt JA, Rayment I . Homologous (beta/alpha)8-barrel enzymes that catalyze unrelated reactions: orotidine 5'-monophosphate decarboxylase and 3-keto-L-gulonate 6-phosphate decarboxylase . Biochemistry . 41 . 12 . 3861–9 . March 2002 . 11900527 . 10.1021/bi012174e .