3-Succinoylsemialdehyde-pyridine dehydrogenase explained

3-Succinoylsemialdehyde-pyridine dehydrogenase
Ec Number:1.2.1.83

3-Succinoylsemialdehyde-pyridine dehydrogenase is an enzyme with systematic name 4-oxo-4-(pyridin-3-yl)butanal:NADP+ oxidoreductase.[1] This enzyme catalyses the following chemical reaction

4-oxo-4-(pyridin-3-yl)butanal + NADP+ + H2O

\rightleftharpoons

4-oxo-4-(pyridin-3-yl)butanoate + NADPH + H+

The enzyme has been characterized from the soil bacterium Pseudomonas sp. HZN6.

Notes and References

  1. Qiu J, Ma Y, Wen Y, Chen L, Wu L, Liu W . Functional identification of two novel genes from Pseudomonas sp. strain HZN6 involved in the catabolism of nicotine . Applied and Environmental Microbiology . 78 . 7 . 2154–60 . April 2012 . 22267672 . 3302611 . 10.1128/AEM.07025-11 .

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