3-Phenylpropanoylfentanyl Explained

3-Phenylpropanoylfentanyl (β'-phenylfentanyl) is an opioid analgesic that is an analog of fentanyl, which was invented in 1981,[1] and has been sold as a designer drug, first identified in March 2017 in Sweden.[2]

Side effects

Side effects of fentanyl analogs are similar to those of fentanyl itself, which include itching, nausea and potentially serious respiratory depression, which can be life-threatening. Fentanyl analogs have killed hundreds of people throughout Europe and the former Soviet republics since the most recent resurgence in use began in Estonia in the early 2000s, and novel derivatives continue to appear.[3] A new wave of fentanyl analogues and associated deaths began in around 2014 in the US, and have continued to grow in prevalence. Since 2016 these drugs have been responsible for hundreds of overdose deaths every week.[4]

Legal status

3-Phenylpropanoylfentanyl was banned in Finland in September 2017,[5] and in Sweden in October 2017.[6] It was also banned in Lithuania in 2017.[7] Banned in United States on April 27, 2021 (schedule 1 of the Controlled Substances Act).[8]

See also

Notes and References

  1. Zhu YQ, Ge GL, Fang SN, Zhu YC, Dai QY, Tan ZY, Huang ZM, Chen XJ . [Studies on potent analgesics. I. Synthesis and analgesic activity of derivatives of fentanyl (author's transl)] . Yao Xue Xue Bao = Acta Pharmaceutica Sinica . 16 . 3 . 199–210 . March 1981 . 6264735 .
  2. Web site: Neue psychoaktive Subst. - Fentanylderivate. . European Union Early Warning System . New psychoactive substances - fentanyl derivatives . 1 June 2017 . German .
  3. Mounteney J, Giraudon I, Denissov G, Griffiths P . Fentanyls: Are we missing the signs? Highly potent and on the rise in Europe . The International Journal on Drug Policy . 26 . 7 . 626–31 . July 2015 . 25976511 . 10.1016/j.drugpo.2015.04.003 .
  4. Armenian P, Vo KT, Barr-Walker J, Lynch KL . Fentanyl, fentanyl analogs and novel synthetic opioids: A comprehensive review . Neuropharmacology . 134. Pt A. October 2017 . 121–132 . 29042317 . 10.1016/j.neuropharm.2017.10.016 . 21404877 .
  5. Web site: Government Decree amending Annex IV to the Government Decree on substances, preparations and plants to be classified as narcotics . European Commission. . Notification detail. . The following 9 new substances are classified: 4-chloro-isobutyrfentanyl, 4-Fluoro-isobutyrfentanyl, 3-phenylpropanoylfentanyl, benzodioxole fentanyl, benzoyl fentanyl, cyclopentyl fentanyl, cyclopropyl fentanyl, methoxyacetyl fentanyl and tetramethylcyclopropyane fentanyl. . 12 September 2017 .
  6. Web site: 14 nya ämnen kan klassas som narkotika eller hälsofarlig vara. . The Public Health Agency of Sweden . 14 new substances can be classified as drugs or health hazards . Swedish . 14 October 2017 .
  7. Web site: dėl narkotinių ir psichotropinių medžiagų nedidelio, didelio ir labai didelio kiekio nustatymo . 1Respublikos Sveikatos Apsaugos Ministro [Ministry of Health Protection of the Republic] . 2003 . 23 . 239 . On the future, large and very large quality of drugs and phytotropic matters . Lithuanian .
  8. Web site: Import/Export Restrictions Finalized on Opioids . ST&R Sandler, Travis & Rosenberg, P.A. . 2021 . English .

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