3-Oxopentanoic acid explained

3-Oxopentanoic acid, or beta-ketopentanoate, is a 5-carbon ketone body. It is made from odd carbon fatty acids in the liver and rapidly enters the brain. As opposed to 4-carbon ketone bodies, beta-ketopentanoate is anaplerotic, meaning it can refill the pool of TCA cycle intermediates. The triglyceride triheptanoin is used clinically to produce beta-ketopentanoate.[1]

Notes and References

  1. Parenteral and Enteral Metabolism of Anaplerotic Triheptanoin in Normal Rats. Renée P. Kinman. Takhar Kasumov. Kathryn A. Jobbins. Katherine R. Thomas. Jillian Adams. Lisa N. Brunengraber. Gerd Kutz. Wolf-Ulrich Brewer. Charles R. Roe. Henri Brunengraber. amp. Am J Physiol Endocrinol Metab. E860–E866. 291. 10.1152/ajpendo.00366.2005. 2006. 16705058. 4. Reprint

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