3-O-alpha-D-mannopyranosyl-alpha-D-mannopyranose xylosylphosphotransferase explained

3-O-alpha-D-mannopyranosyl-alpha-D-mannopyranose xylosylphosphotransferase
Ec Number:2.7.8.32

3-O-alpha-D-mannopyranosyl-alpha-D-mannopyranose xylosylphosphotransferase (XPT1) is an enzyme with systematic name UDP-D-xylose:3-O-alpha-D-mannopyranosyl-alpha-D-mannopyranose xylosylphosphotransferase.[1] This enzyme catalyses the following chemical reaction

UDP-xylose + 3-O-alpha-D-mannopyranosyl-alpha-D-mannopyranose

\rightleftharpoons

UMP + 3-O-(6-O-alpha-D-xylosylphospho-alpha-D-mannopyranosyl)-alpha-D-mannopyranose

Mn2+ required for activity.

Notes and References

  1. Reilly MC, Levery SB, Castle SA, Klutts JS, Doering TL . A novel xylosylphosphotransferase activity discovered in Cryptococcus neoformans . The Journal of Biological Chemistry . 284 . 52 . 36118–27 . December 2009 . 19864415 . 2794727 . 10.1074/jbc.m109.056226 . free .