3-Methyl-PCPy explained

Drug Name:	3-Me-PCPy
Iupac Name:	1-[1-(3-methylphenyl)cyclohexyl]pyrrolidine
Legal Ca:	Schedule I
Legal Uk:	Class B
Legal De:	NpSG
Cas Number:	1622348-63-3
Atc Prefix:	None
Pubchem:	137332188
Unii:	FS9Z5C7CQ5
C:	17
H:	25
N:	1
Smiles:	CC1=CC(=CC=C1)C2(CCCCC2)N3CCCC3
Stdinchi:	1S/C17H25N/c1-15-8-7-9-16(14-15)17(10-3-2-4-11-17)18-12-5-6-13-18/h7-9,14H,2-6,10-13H2,1H3
Stdinchikey:	JZVMREFYFTZXGN-UHFFFAOYSA-N

3-Methyl-PCPy (3-Me-PCPy) is an arylcyclohexylamine derivative with an unusual spectrum of pharmacological effects, acting as both a potent NMDA antagonist and also a triple reuptake inhibitor which inhibits reuptake of all three monoamine neurotransmitters serotonin, dopamine and noradrenaline. It also acts as a high affinity sigma receptor ligand, selective for the σ₂ subtype. It produces both stimulant and dissociative effects in animal behavioural studies.^{[1] [2] [3]}

Legal Status

3-Methyl-PCPy is covered by drug analogue laws in various jurisdictions (UK, Germany, Japan, Australia etc.) as a generic arylcyclohexylamine derivative, and a structural isomer of phencyclidine.

See also

• 3-Methyl-PCP
• BTCP
• Deoxymethoxetamine
• Ephenidine
• MDPCP

Notes and References

1. Wallach J, De Paoli G, Adejare A, Brandt SD . Preparation and analytical characterization of 1-(1-phenylcyclohexyl)piperidine (PCP) and 1-(1-phenylcyclohexyl)pyrrolidine (PCPy) analogues . Drug Testing and Analysis . 6 . 7–8 . 633–50 . 2014 . 23554350 . 10.1002/dta.1468 .
2. Morris H, Wallach J . From PCP to MXE: a comprehensive review of the non-medical use of dissociative drugs . Drug Testing and Analysis . 6 . 7–8 . 614–32 . 2014 . 24678061 . 10.1002/dta.1620 .
3. Book: Wallach J, Brandt SD . New Psychoactive Substances . Phencyclidine-Based New Psychoactive Substances . Handbook of Experimental Pharmacology . 252 . 261–303 . 2018 . 30105474 . 10.1007/164_2018_124 . 978-3-030-10560-0 .